{"product_id":"pe-22-28","title":"PE-22-28","description":"\u003ch3\u003eSynthetic Peptide for Neuropharmacology Research\u003c\/h3\u003e\n\u003ch3\u003eTechnical Overview\u003c\/h3\u003e\n\u003cp\u003ePE-22-28 10mg is a synthetic peptide compound developed for laboratory research involving two-pore-domain potassium channel modulation, receptor interaction analysis, and controlled experimental investigation. In research settings, this peptide is commonly utilized for studying TREK-1 channel function, synaptic plasticity and mood-circuit signaling, and related biochemical mechanisms.\u003c\/p\u003e\n\u003cp\u003ePE-22-28 is a heptapeptide fragment corresponding to the C-terminal 22-28 region of spadin, the propeptide released during sortilin maturation. It selectively inhibits the TREK-1 (KCNK2) two-pore-domain potassium channel, modulating neuronal excitability in preparations from cortex, hippocampus, and dorsal raphe.\u003c\/p\u003e\n\u003cp\u003eResearchers employ PE-22-28 to probe TREK-1 contributions to fast-onset antidepressant signaling, neurogenesis, and serotonergic activity in rodent brain-slice and primary-culture models. Its relative ease of synthesis compared to full-length spadin makes it the preferred tool compound for TREK-1 antagonism studies.\u003c\/p\u003e\n\u003cp\u003eThis compound is synthesized using established solid-phase peptide synthesis methods and purified through reversed-phase HPLC to achieve analytical purity suitable for laboratory assays, binding studies, and analytical applications. The lyophilized material is supplied for reconstitution per established laboratory protocols and is intended as a reference material in controlled research environments.\u003c\/p\u003e\n\u003ch3\u003eSpecifications\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eCompound Name:\u003c\/strong\u003e PE-22-28\u003cbr\u003e\u003cstrong\u003eStrength:\u003c\/strong\u003e 10mg\u003cbr\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥ 99% (HPLC Verified)\u003cbr\u003e\u003cstrong\u003eAppearance:\u003c\/strong\u003e Lyophilized Peptide Powder\u003cbr\u003e\u003cstrong\u003eFormat:\u003c\/strong\u003e Research Compound\u003cbr\u003e\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Suitable for laboratory assay preparation.\u003c\/p\u003e\n\u003ch3\u003eNotice\u003c\/h3\u003e\n\u003cp\u003eProvided as a reference material for scientific investigation only.\u003c\/p\u003e","brand":"American Peptides","offers":[{"title":"10 mg","offer_id":48615148060827,"sku":"PE22-10","price":70.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0751\/2876\/6619\/files\/pe-22-28-normalized.png?v=1780880432","url":"https:\/\/www.americanpeptides.us\/products\/pe-22-28","provider":"American Peptides","version":"1.0","type":"link"}