Research Compound Reference
Cagrilintide
Cagrilintide, also cataloged as AM833, is a synthetic long-acting analogue of human amylin (islet amyloid polypeptide) supplied as a lyophilized powder for laboratory research use only. It carries CAS number 1415456-99-3 and a molecular formula of C194H312N54O59S2 with an average molecular weight of approximately 4409 g/mol.
Molecular profile of Cagrilintide| CAS Number | 1415456-99-3 |
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| Molecular Formula | C194H312N54O59S2 |
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| Molecular Weight | 4409 g/mol (average) |
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| Amino Acid Count | 37 |
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| Sequence | 32-residue amylin analogue, lipidated (see COA for lot-specific characterization) |
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| Purity | ≥99% by HPLC · COA available |
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| Physical Form | Lyophilized powder |
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What is Cagrilintide?
Cagrilintide is a 32-residue amylin analogue modified with a lipid side chain, a structural strategy used in peptide chemistry to extend circulating half-life by promoting reversible albumin association. Amylin itself is a pancreatic islet peptide co-secreted with insulin, and analogues of it are studied in receptor-pharmacology literature for their interaction with the calcitonin receptor and receptor-activity-modifying protein (RAMP) complexes that together form the amylin receptor family. Cagrilintide is supplied here as a research chemical for in-vitro and analytical work; its molecular formula is C194H312N54O59S2 with an average molecular weight of approximately 4409 g/mol, and it is registered under CAS 1415456-99-3. It is an investigational compound and is not approved by the FDA for any use.
Reconstitution & handling
For laboratory handling, lyophilized cagrilintide is typically brought into solution with sterile water or a suitable aqueous buffer. As a lipidated peptide it is more surface-active than an unmodified sequence, so gentle swirling rather than vigorous agitation is the usual laboratory practice to limit foaming and adsorption losses at the air-liquid interface. Solubility behaviour should be established empirically for the buffer system in use.
Storage & stability
The lyophilized powder is best stored at -20 C in a sealed, desiccated container protected from light, conditions under which peptide powders are generally stable long-term. Once in solution, peptides are markedly less stable than in the dry state; laboratories typically aliquot to avoid repeated freeze-thaw cycles. Refer to the lot label for the expiration date.
How it's tested
Each lot is characterized by reversed-phase high-performance liquid chromatography (HPLC) to establish purity, with identity confirmed by mass spectrometry. A third-party Certificate of Analysis is available and can be matched to the lot number printed on the vial label.
Frequently asked questions
What is cagrilintide?
Cagrilintide (also cataloged as AM833) is a synthetic long-acting analogue of human amylin, a 32-residue peptide modified with a lipid side chain. It is supplied as a lyophilized powder for laboratory research use only and is not a drug, food, or cosmetic.
What is the molecular formula and weight of cagrilintide?
The molecular formula is C194H312N54O59S2 with an average molecular weight of approximately 4409 g/mol (PubChem CID 171397054). Its CAS registry number is 1415456-99-3.
What receptor family does the amylin literature associate with cagrilintide?
Published receptor-pharmacology work on amylin analogues describes interaction with the amylin receptor family, formed by the calcitonin receptor in complex with receptor-activity-modifying proteins (RAMP1, RAMP2, RAMP3). This is a description of in-vitro receptor pharmacology, not a statement about outcomes in humans.
Is cagrilintide approved by the FDA?
No. Cagrilintide is an investigational compound. It is not approved by the FDA for any indication, and material supplied here is for laboratory research use only.
How should cagrilintide be stored?
Store the lyophilized powder at -20 C, sealed, desiccated, and protected from light. Peptides in solution are considerably less stable than the dry powder, so aliquoting to avoid repeated freeze-thaw cycles is standard laboratory practice.
Is a Certificate of Analysis available?
Yes. Every lot is third-party tested by HPLC for purity with identity confirmed by mass spectrometry, and the COA can be looked up by the lot number printed on the vial label.
Shop lot-tested Cagrilintide
Third-party tested to ≥99% purity, with analytical documentation available.
Related compounds
This reference describes the compound's chemistry and analytical properties for laboratory research use only. It is not medical advice; the product is not a drug, supplement, or cosmetic and is not for human or veterinary consumption.
