Research Compound Reference
Humanin
Humanin is a 24-residue mitochondrial-derived peptide (MDP) encoded within the mitochondrial 16S ribosomal RNA gene, supplied as a lyophilized powder for laboratory research use only. It carries CAS number 330936-69-1 and a molecular formula of C119H204N34O32S2 with an average molecular weight of approximately 2687.2 g/mol.
Molecular profile of Humanin| CAS Number | 330936-69-1 |
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| Molecular Formula | C119H204N34O32S2 |
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| Molecular Weight | 2687.2 g/mol (average) |
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| Amino Acid Count | 24 |
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| Sequence | MAPRGFSCLLLLTSEIDLPVKRRA |
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| Purity | ≥99% by HPLC · COA available |
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| Physical Form | Lyophilized powder |
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What is Humanin?
Humanin was the first described member of the mitochondrial-derived peptide family — short peptides whose open reading frames sit inside mitochondrial ribosomal RNA genes rather than in nuclear DNA. Its 24-amino-acid sequence is MAPRGFSCLLLLTSEIDLPVKRRA. In cell-biology literature humanin is studied as a signalling peptide, with in-vitro work describing interaction with a trimeric receptor complex and with members of the Bcl-2 protein family; this is mechanistic cell-culture research and does not establish any outcome in humans. The compound is supplied here as a research chemical with a molecular formula of C119H204N34O32S2, an average molecular weight of approximately 2687.2 g/mol, and CAS registry number 330936-69-1. It is not approved by the FDA for any use.
Reconstitution & handling
For laboratory handling, lyophilized humanin is typically dissolved in sterile water or a suitable aqueous buffer. The sequence contains a cysteine residue and a hydrophobic leucine-rich stretch, so laboratories commonly establish solubility empirically in their chosen buffer and prepare solutions fresh where oxidation of the free thiol is a concern.
Storage & stability
Store the lyophilized powder at -20 C in a sealed, desiccated container protected from light. Peptide powders are generally stable long-term under these conditions, while solutions are not; aliquoting to avoid repeated freeze-thaw cycles is standard practice. Refer to the lot label for the expiration date.
How it's tested
Each lot is characterized by reversed-phase high-performance liquid chromatography (HPLC) to establish purity, with identity confirmed by mass spectrometry. A third-party Certificate of Analysis is available and can be matched to the lot number printed on the vial label.
Frequently asked questions
What is humanin?
Humanin is a 24-residue mitochondrial-derived peptide (sequence MAPRGFSCLLLLTSEIDLPVKRRA) encoded within the mitochondrial 16S rRNA gene. It is supplied as a lyophilized powder for laboratory research use only and is not a drug, food, or cosmetic.
What is the molecular formula and weight of humanin?
The molecular formula is C119H204N34O32S2 with an average molecular weight of approximately 2687.2 g/mol (PubChem CID 16131438). Its CAS registry number is 330936-69-1.
What is a mitochondrial-derived peptide?
Mitochondrial-derived peptides are short peptides whose coding sequences lie within mitochondrial ribosomal RNA genes rather than in nuclear DNA. Humanin was the first member of this family to be described, and the group is an active subject of cell-biology literature.
Is humanin approved by the FDA?
No. Humanin is not approved by the FDA for any indication. Material supplied here is a research chemical for laboratory use only.
How should humanin be stored?
Store the lyophilized powder at -20 C, sealed, desiccated, and protected from light. Solutions are less stable than the dry powder, so laboratories typically aliquot to avoid repeated freeze-thaw cycles.
Is a Certificate of Analysis available?
Yes. Every lot is third-party tested by HPLC for purity with identity confirmed by mass spectrometry, and the COA can be looked up by the lot number printed on the vial label.
Shop lot-tested Humanin
Third-party tested to ≥99% purity, with analytical documentation available.
Related compounds
This reference describes the compound's chemistry and analytical properties for laboratory research use only. It is not medical advice; the product is not a drug, supplement, or cosmetic and is not for human or veterinary consumption.
